September 29 , 2005

FOR IMMEDIATE RELEASE

Aspreva Announces Achievement of Targeted Patient Enrolment in Phase III Clinical Trial for CellCept in Lupus Nephritis

Victoria, B.C., Canada; September 29, 2006 – Aspreva Pharmaceuticals Corporation (NASDAQ: ASPV; TSX: ASV), an emerging pharmaceutical company focused on increasing the pool of evidence-based medicines available for patients living with less common diseases, today announced the completion of the targeted enrolment of 358 patients in its global phase III clinical trial for CellCept® (mycophenolate mofetil) in the treatment of lupus nephritis. The study is assessing the safety and efficacy of CellCept in inducing response and maintaining remission in patients with biopsy-proven lupus nephritis.

The two-phase induction and maintenance study is a randomized open-label comparison of mycophenolate mofetil with the current standard of care, intravenous cyclophosphamide, for the first six months or induction phase, followed by a double-blind comparison of mycophenolate mofetil with azathioprine for up to three years or maintenance phase. The primary end point for the induction phase is an improvement in proteinuria and stabilization of serum creatinine. The Company expects database lock on the induction phase of the study in the second quarter of 2007 with submission of an sNDA to the United States Food and Drug Administration (FDA) in the fourth quarter of 2007.

Dr. Richard Jones, Senior Vice President, Clinical and Regulatory Affairs at Aspreva, said, “Our clinical trial in lupus nephritis is our largest phase III study currently underway, and we are very pleased with our rapid development in this challenging clinical area. The successful completion of targeted patient enrolment reflects the cooperation between Aspreva, key opinion leaders, advocacy groups and the medical community, which together enabled us to attract patients and physicians to our clinical trial in this complex disease area. We couldn’t achieve this success without the global support of our employees, our partner, Roche, and the patients and physicians represented by the 117 global clinical sites. We look forward to sharing clinical results upon completion of this trial and the associated regulatory filings to follow.”

About Lupus Nephritis
Systemic lupus erythematosus (SLE), commonly called lupus, is a chronic autoimmune disease that causes the body to attack its own tissues and joints.

Lupus nephritis is the most serious manifestation of the disease, which, if left untreated, can lead to kidney failure, requiring dialysis. It is a complicated disease as patients typically fluctuate between periods of intense disease activity when the patient’s own immune system is actively attacking and causing damage in their kidney, interspersed with periods of remission. Clinicians estimate that one third to one half of lupus patients have lupus nephritis.

There has been no new approved treatment for SLE or lupus nephritis in the United States in over thirty years. Current treatments involve the off-label use of existing cancer drugs such as cyclophosphamide, steroids, and other immunosuppressant drugs such as azathioprine.

About CellCept
CellCept is Roche’s leading immunosuppressant or "anti-rejection" drug used in combination with other immunosuppressive drugs (cyclosporine and corticosteroids) for the prevention of rejection in patients receiving heart, kidney and liver transplants. CellCept was first approved for use in combination therapy for the prevention of acute organ rejection in kidney transplantation in 1995 and has since been approved worldwide for prevention of organ rejection in adult kidney, heart and liver transplantation. In some countries, it has also been approved for paediatric kidney transplantation. This therapeutic success represents 11 years of clinical experience and patient benefits, including reduced toxicities and prolonged graft and patient survival. Over the last decade, CellCept has become the world's most widely studied immunosuppressant and research is ongoing both in organ transplantation and related areas, such as autoimmune disease, to help provide clinical benefit to a wider range of patients.

In July 2003, Aspreva signed a collaboration agreement with Roche for the exclusive worldwide rights (excluding Japan) to develop and, upon regulatory approval, commercialize CellCept for all autoimmune disease applications.

About Aspreva Pharmaceuticals
Aspreva is an emerging pharmaceutical company focused on identifying, developing and, upon regulatory approval, commercializing new indications for approved drugs and late stage drug candidates for patients living with less common diseases. Aspreva is listed on the Nasdaq Global Select Market under the trading symbol "ASPV" and on the Toronto Stock Exchange under the trading symbol "ASV".

For further information please contact:
Sage Baker
Vice President, Investor Relations and Corporate Communications
Aspreva Pharmaceuticals
250-744-2488 ext. 270
sbaker@aspreva.com

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